Premium
Polarization Transfer over the Water–Protein Interface in Solids
Author(s) -
Lesage Anne,
Gardiennet Carole,
Loquet Antoine,
Verel René,
Pintacuda Guido,
Emsley Lyndon,
Meier Beat H.,
Böckmann Anja
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801110
Subject(s) - polarization (electrochemistry) , spin diffusion , intermolecular force , chemistry , chemical physics , electron transfer , diffusion , analytical chemistry (journal) , crystallography , physics , molecule , chromatography , thermodynamics , organic chemistry
A key to the elucidation of protein functions are water–protein interactions. The determination of polarization‐transfer pathways between water and immobilized proteins demonstrates that chemical exchange (sometimes followed by spin diffusion) is the dominant mechanism. At low temperatures or high spinning frequencies, this pathway becomes inefficient, and intermolecular NOEs are observed (see NMR spectra; ROE=rotating frame NOE).