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Uncovering a Latent Ligation Site for Glycopeptide Synthesis
Author(s) -
Okamoto Ryo,
Kajihara Yasuhiro
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801097
Subject(s) - glycopeptide , ligation , computer science , computational biology , medicine , chemistry , biology , biochemistry , antibiotics
Serine in site : A native chemical ligation concept at the serine site is described (see picture). This method was achieved by the CNBr conversion reaction from methylcysteine, which could be obtained by selective S methylation. This new method allowed a consensus sequence that is generally incorporated in N‐linked oligosaccharides to be used as a ligation site in the course of glycopeptide synthesis.
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