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Functionalized Nanocompartments (Synthosomes) with a Reduction‐Triggered Release System
Author(s) -
Onaca Ozana,
Sarkar Pransenjit,
Roccatano Danilo,
Friedrich Thomas,
Hauer Bernard,
Grzelakowski Mariusz,
Güven Arcan,
Fioroni Marco,
Schwaneberg Ulrich
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801076
Subject(s) - transmembrane protein , reduction (mathematics) , block (permutation group theory) , chemistry , copolymer , combinatorial chemistry , steric effects , transmembrane domain , computer science , membrane , stereochemistry , biochemistry , mathematics , organic chemistry , combinatorics , geometry , receptor , polymer
An open and shut case : The developed synthosomes are a subclass of polymersomes with a block‐copolymer membrane and a modified embedded transmembrane channel protein (FhuA Δ1–160; see top view of model), which acts as a selective gate. The first reduction‐triggered and sterically controlled release system for transmembrane control of the chemical fluxes has been developed by chemically labeling lysine residues in the channel of FhuA Δ1–160.