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Organogelation of Sheet–Helix Diblock Copolypeptides
Author(s) -
Gibson Matthew I.,
Cameron Neil R.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801056
Subject(s) - block (permutation group theory) , random coil , chemistry , solubility , helix (gastropod) , crystallography , computer science , stereochemistry , polymer science , circular dichroism , organic chemistry , combinatorics , biology , mathematics , ecology , snail
Together they're strong : Block copolypeptides containing poly(benzyl‐ L ‐threonine) and an α‐helical block are effective organogelators despite the high solubility of the constituent homopolymers. An unexpected conformational change in the first block, from random coil to β sheet, directs the assembly into stacked lamellae (see picture).