Activation and Stabilization of Drugs by Supramolecular p K  a  Shifts: Drug‐Delivery Applications Tailored for Cucurbiturils | Zendy

Saleh Na'il | Zendy; Koner Apurba L. | Zendy; Nau Werner M. | Zendy

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Activation and Stabilization of Drugs by Supramolecular p K a Shifts: Drug‐Delivery Applications Tailored for Cucurbiturils

Author(s) -

Saleh Na'il,

Koner Apurba L.,

Nau Werner M.

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200801054

Subject(s) - lansoprazole , cucurbituril , supramolecular chemistry , drug , combinatorial chemistry , chemistry , drug delivery , omeprazole , stereochemistry , pharmacology , organic chemistry , medicine , molecule

Controlling the drug supply : UV and NMR spectroscopic studies show that drugs such as omeprazole and lansoprazole, popular drugs for the treatment of gastric acid related diseases, are stable for several weeks by using cucurbit[7]uril as a macrocyclic host (see scheme). The drugs are also more rapidly converted into their active forms by an acid‐promoted reaction catalyzed by a supramolecular p K a shift.

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