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Activation and Stabilization of Drugs by Supramolecular p K a Shifts: Drug‐Delivery Applications Tailored for Cucurbiturils
Author(s) -
Saleh Na'il,
Koner Apurba L.,
Nau Werner M.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801054
Subject(s) - lansoprazole , cucurbituril , supramolecular chemistry , drug , combinatorial chemistry , chemistry , drug delivery , omeprazole , stereochemistry , pharmacology , organic chemistry , medicine , molecule
Controlling the drug supply : UV and NMR spectroscopic studies show that drugs such as omeprazole and lansoprazole, popular drugs for the treatment of gastric acid related diseases, are stable for several weeks by using cucurbit[7]uril as a macrocyclic host (see scheme). The drugs are also more rapidly converted into their active forms by an acid‐promoted reaction catalyzed by a supramolecular p K a shift.