Premium
Highly Enantioselective Zinc/Binol‐Catalyzed Alkynylation of N ‐Sulfonyl Aldimines
Author(s) -
Blay Gonzalo,
Cardona Luz,
Climent Estela,
Pedro José R.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200801020
Subject(s) - enantioselective synthesis , aldimine , alkynylation , sulfonyl , catalysis , zinc , chemistry , combinatorial chemistry , organic chemistry , alkyl
It all adds up with zinc : Terminal alkynes react with N ‐tosyl aldimines in the presence of dimethylzinc and binol‐type ligands to give to N ‐tosyl‐protected propargylic amines with good yields and high enantiomeric excesses (up to more than 99 %; see scheme).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom