Total Synthesis of Chondramide C and Its Binding Mode to F‐Actin | Zendy

Waldmann Herbert | Zendy; Hu TaiShan | Zendy; Renner Steffen | Zendy; Menninger Sascha | Zendy; Tannert René | Zendy; Oda Toshiro | Zendy; Arndt HansDieter | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Total Synthesis of Chondramide C and Its Binding Mode to F‐Actin

Author(s) -

Waldmann Herbert,

Hu TaiShan,

Renner Steffen,

Menninger Sascha,

Tannert René,

Oda Toshiro,

Arndt HansDieter

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200801010

Subject(s) - actin , protein filament , chemistry , polyketide , metathesis , computational biology , stereochemistry , computer science , docking (animal) , polymerization , biology , biochemistry , polymer , gene , organic chemistry , biosynthesis , medicine , nursing

Actin glue: An E ‐selective ring‐closing metathesis as the key step allowed the solid‐phase‐based total synthesis of the F‐actin stabilizer chondramide C as well as the establishment of its hitherto unknown stereochemistry. A strong influence of the polyketide configuration was revealed in cellular assays. Docking studies on the F‐actin filament structure led to a detailed model of the binding site.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research