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Palladium Catalysts for the Formylation of Vinyl Triflates To Form α,β‐Unsaturated Aldehydes
Author(s) -
Neumann Helfried,
Sergeev Alexey,
Beller Matthias
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800994
Subject(s) - palladium , formylation , catalysis , benzene , denticity , chemistry , ring (chemistry) , ligand (biochemistry) , transformation (genetics) , combinatorial chemistry , organic chemistry , medicinal chemistry , metal , receptor , biochemistry , gene
What a gas! Synthesis gas is the formylating agent in the efficient one‐step title transformation promoted by a palladium catalyst with the bidentate ligand 1,2‐bis(di‐1‐adamantylphosphinomethyl)benzene (see scheme). This method enables the conversion of six‐ to eight‐membered‐ring triflates into α,β‐unsaturated aldehydes and the introduction of a formyl group into derivatives of elaborate natural compounds. Tf=trifluoromethanesulfonyl.
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