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From Metal Complexes to Nanominerals: The Formation of Inorganic Nanoparticles on Fibrils of Transferrin
Author(s) -
Epple Matthias
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800930
Subject(s) - fibril , transferrin , chemistry , mineralization (soil science) , amyloid fibril , metal , nanoparticle , collagen fibril , biophysics , crystallography , chemical engineering , nanotechnology , biochemistry , materials science , organic chemistry , amyloid β , biology , medicine , disease , pathology , nitrogen , engineering
Upon drying of the iron transport protein transferrin (hTf), the originally individually coordinated Fe forms crystalline deposits of FeO(OH) (“rust”), which are periodically arranged on fibrils of the protein. This is also true for Mn and Bi minerals (the picture shows mineralization on hTF fibrils; holo/apo‐hTf: hTf with/without Fe). A mineralization of this kind on fibrils could play a role in neurodegenerative diseases such as Alzheimer's.