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Screening Potential Antitumor Agents from Natural Plant Extracts by G‐Quadruplex Recognition and NMR Methods
Author(s) -
Zhou Qiuju,
Li Lin,
Xiang Junfeng,
Tang Yalin,
Zhang Hong,
Yang Shu,
Li Qian,
Yang Qianfan,
Xu Guangzhi
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800913
Subject(s) - nuclear magnetic resonance spectroscopy , g quadruplex , chemistry , combinatorial chemistry , detection limit , two dimensional nuclear magnetic resonance spectroscopy , spectroscopy , chromatography , stereochemistry , biochemistry , dna , physics , quantum mechanics
Weeding out ligands : Rapid screening of G‐quadruplex ligands in plant extracts is achieved by the combination of G‐quadruplex recognition (see picture) with 1 H NMR spectroscopy, diffusion‐ordered spectroscopy (DOSY), and 2D NMR techniques. The method has a low detection limit and allows the structures of the ligands to be identified.