Which Oxidant Is Really Responsible for P450 Model Oxygenation Reactions? A Kinetic Approach | Zendy

Franke Alicja | Zendy; Fertinger Christoph | Zendy; van Eldik Rudi | Zendy

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Which Oxidant Is Really Responsible for P450 Model Oxygenation Reactions? A Kinetic Approach

Author(s) -

Franke Alicja,

Fertinger Christoph,

van Eldik Rudi

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200800907

Subject(s) - heterolysis , chemistry , catalysis , kinetic energy , substrate (aquarium) , cleavage (geology) , bond cleavage , oxygen , kinetics , oxygenation , medicinal chemistry , photochemistry , organic chemistry , materials science , physics , ecology , quantum mechanics , fracture (geology) , composite material , biology

A rate‐fate fête : Direct kinetic studies on epoxidation and sulfoxidation reactions revealed that the oxygenating capability of [(TMP +. )Fe IV O] is orders of magnitude higher than that of [Fe III (TMP)( m ‐CPBA)]. Under catalytic turnover conditions, the relative ratio between the rate of OO bond heterolytic cleavage and the rate of oxygen transfer from the [Fe III (TMP)( m ‐CPBA)] intermediate to the substrate, should be taken into consideration. m ‐CPBA =m ‐chloroperbenzoic acid, TMP= meso ‐tetramesitylporphyrin.

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