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Traveling the Vitamin B 12 Pathway: Oral Delivery of Protein and Peptide Drugs
Author(s) -
Petrus Amanda K.,
Fairchild Timothy J.,
Doyle Robert P.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800865
Subject(s) - peptide , oral administration , pharmacology , medicine , route of administration , oral route , chemistry , biochemistry
Abstract Oral routes of administration for therapeutic peptides and proteins face two major barriers: proteolytic degradation in the stomach and an inadequate absorption mechanism for polypeptides within the intestinal lumen. As a result, peptide‐based therapeutics are administered by injection, a painful process associated with lower patient compliance. The development of a means of overcoming these two major obstacles and enabling the successful delivery of peptide therapeutics by the oral route of administration has therefore been the target of extensive scientific endeavor. This Minireview focuses on oral peptide/protein delivery by the dietary uptake pathway for vitamin B 12 . Recent progress in this field includes the delivery of erythropoietin, granulocyte‐colony‐stimulating factor, luteinizing‐hormone‐releasing hormone, and insulin.