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Construction and Screening of a 2‐Aminoimidazole Library Identifies a Small Molecule Capable of Inhibiting and Dispersing Bacterial Biofilms across Order, Class, and Phylum
Author(s) -
Rogers Steven A.,
Melander Christian
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800862
Subject(s) - biofilm , phylum , order (exchange) , bacteria , microbiology and biotechnology , cystic fibrosis , class (philosophy) , world wide web , computer science , biology , chemistry , business , genetics , finance , artificial intelligence
A team of three : 2‐Aminoimidazole, triazole, and tether units together resulted in conjugates (see picture, n =4–6 for the most active compounds) that are capable of inhibiting and dispersing bacteria biofilms without inducing bacterial death. Such biofilms have been implicated in a plethora of medical problems, including infection of implanted medical devices and the mortality of cystic fibrosis patients.