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Regioselective Synthesis of γ‐Amino Esters, Nitriles, Sulfones, and Pyrrolidinones by Nickel‐Catalyzed Reductive Coupling of Aldimines and Activated Alkenes
Author(s) -
Yeh ChienHung,
Prasad Korivi Rajendra,
Cheng ChienHong
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800825
Subject(s) - alkene , pyrrolidinones , aldimine , chemistry , regioselectivity , catalysis , nickel , combinatorial chemistry , organic chemistry
A couple of alternatives : An efficient method has been developed for the synthesis of γ‐amino derivatives and pyrrolidinones from readily available starting materials by using a nickel–phenanthroline complex (see scheme). The reaction proceeds by the formation of a CC bond at the β‐carbon atom, instead of the more usual α‐carbon atom, of a conjugated alkene via an azanickelacycle intermediate.