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Bridging One Helical Turn in Double‐Stranded DNA by Templated Dimerization of Molecular Rods
Author(s) -
Andersen Casper S.,
Yan Hao,
Gothelf Kurt V.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800819
Subject(s) - salicylaldehyde , dna , chemistry , molecule , stereochemistry , ethylenediamine , base pair , conjugated system , bridging (networking) , combinatorial chemistry , crystallography , polymer , computer science , biochemistry , organic chemistry , schiff base , computer network
A molecular bridge : A molecular rod composed of a substituted oligo(phenylene ethynylene) backbone with salicylaldehyde moieties in the terminal positions was conjugated to short 10‐base‐pair DNA sequences (shown in red). The assembly of two such conjugates on a DNA template (blue) aligns the two molecules for reaction in the presence of ethylenediamine and a metal salt to form a metal–salen complex.