Bridging One Helical Turn in Double‐Stranded DNA by Templated Dimerization of Molecular Rods | Zendy

Andersen Casper S. | Zendy; Yan Hao | Zendy; Gothelf Kurt V. | Zendy

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Bridging One Helical Turn in Double‐Stranded DNA by Templated Dimerization of Molecular Rods

Author(s) -

Andersen Casper S.,

Yan Hao,

Gothelf Kurt V.

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200800819

Subject(s) - salicylaldehyde , dna , chemistry , molecule , stereochemistry , ethylenediamine , base pair , conjugated system , bridging (networking) , combinatorial chemistry , crystallography , polymer , computer science , biochemistry , organic chemistry , schiff base , computer network

A molecular bridge : A molecular rod composed of a substituted oligo(phenylene ethynylene) backbone with salicylaldehyde moieties in the terminal positions was conjugated to short 10‐base‐pair DNA sequences (shown in red). The assembly of two such conjugates on a DNA template (blue) aligns the two molecules for reaction in the presence of ethylenediamine and a metal salt to form a metal–salen complex.

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