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Binding of Aminoglycoside Antibiotics to the Duplex Form of the HIV‐1 Genomic RNA Dimerization Initiation Site
Author(s) -
Freisz Séverine,
Lang Kathrin,
Micura Ronald,
Dumas Philippe,
Ennifar Eric
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800726
Subject(s) - aminoglycoside , duplex (building) , rna , antibiotics , human immunodeficiency virus (hiv) , binding site , computational biology , biology , virology , chemistry , genetics , dna , gene
Targeting HIV RNA : High‐resolution X‐ray structures of the HIV‐1 genomic RNA dimerization initiation site (DIS) extended duplex bound to several aminoglycoside antibiotics have been obtained (see ribostamycin complex as an example). They show the feasibility of targeting viral RNA with small drugs, and open up the possibility of structure‐based rational drug design aimed against viral replication.