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Cyclic Peptides Bearing a Side‐Chain Tail: A Tool to Model the Structure and Reactivity of Protein Zinc Sites
Author(s) -
Sénèque Olivier,
Bourlès Emilie,
Lebrun Vincent,
Bonnet Estelle,
Dumy Pascal,
Latour JeanMarc
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800677
Subject(s) - chemistry , humanities , philosophy
A near‐perfect model : The design of short peptides with cyclic and linear components allows mimicking of the structure and reactivity of protein tetracysteinate zinc sites, as illustrated by the superposition of the Zn(Cys) 4 site of Hsp33 (blue) and its 20 amino acid model (green).
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