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Total Synthesis of Polyoxygenated Cembrenes
Author(s) -
Tietze Lutz F.,
Brazel C. Christian,
Hölsken Sören,
Magull Jörg,
Ringe Arne
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800626
Subject(s) - domino , metathesis , key (lock) , stereoselectivity , closing (real estate) , ring closing metathesis , computer science , alkylation , stereochemistry , content (measure theory) , chemistry , mathematics , organic chemistry , political science , operating system , law , catalysis , polymerization , polymer , mathematical analysis
A convergent approach for the stereoselective construction of polyoxygenated cembrenes is reported. Key steps in the synthesis are an asymmetric domino multicomponent allylation, a modified Myers α‐alkylation, and a ring‐closing metathesis.