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Biaryl Phosphane Ligands in Palladium‐Catalyzed Amination
Author(s) -
Surry David S.,
Buchwald Stephen L.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800497
Subject(s) - amination , palladium , catalysis , chemistry , aryl , halide , natural product , context (archaeology) , combinatorial chemistry , organic chemistry , coupling reaction , paleontology , alkyl , biology
Palladium‐catalyzed amination reactions of aryl halides have undergone rapid development in the last 12 years, largely driven by the implementation of new classes of ligands. Biaryl phosphanes have proven to provide especially active catalysts in this context. This Review discusses the application of these catalysts in CN cross‐coupling reactions in the synthesis of heterocycles and pharmaceuticals, in materials science, and in natural product synthesis.