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Catalytic Three‐Component Ugi Reaction
Author(s) -
Pan Subhas Chandra,
List Benjamin
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800494
Subject(s) - catalysis , ugi reaction , component (thermodynamics) , chemistry , primary (astronomy) , atom economy , combinatorial chemistry , amino acid , organic chemistry , isocyanide , biochemistry , physics , astronomy , thermodynamics
Perfect atom economy characterizes a novel catalytic three‐component Ugi reaction (see example). Different α‐amino amides are formed in good yields from aldehydes, primary amines, and isocyanides in the presence of phenyl phosphinic acid as the catalyst. The products will be useful for the synthesis of α‐amino acid derivatives and in diversity‐oriented synthesis.