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Total Synthesis of Enzyme Inhibitor Spirastrellolide A—Stereochemical Confirmation
Author(s) -
Perkins Michael V.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800486
Subject(s) - total synthesis , stereochemistry , isolation (microbiology) , chemistry , enzyme , modular design , combinatorial chemistry , biochemistry , computer science , biology , bioinformatics , operating system
Problem solved : Spirastrellolide A methyl ester (see picture) is a potent phosphatase 2A inhibitor and has been the subject of considerable synthetic interest since its isolation in 2003. Paterson and co‐workers have now succeeded in the total synthesis of this compound by using a flexible modular strategy. This total synthesis and previous studies towards fragments for spectroscopic comparison and stereochemical determination is summarized.