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A Metal‐Mediated Conformational Switch Controls G‐Quadruplex Binding Affinity
Author(s) -
Monchaud David,
Yang Peng,
Lacroix Laurent,
TeuladeFichou MariePaule,
Mergny JeanLouis
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800468
Subject(s) - ligand (biochemistry) , g quadruplex , chemistry , dna , small molecule , molecule , stereochemistry , molecular switch , combinatorial chemistry , molecular model , biophysics , crystallography , receptor , biochemistry , biology , organic chemistry
Control by copper : Cu II ions modulate the quadruplex affinity of the high‐affinity ligand 360A and denaturate the folded quadruplex form of DNA 22AG to an unfolded form. So removal of copper through complexation enables the cycling of both 360A quadruplex affinity and quadruplex unfolding.