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Enantioselective Rhodium‐Catalyzed Addition of Arylboronic Acids to α‐Ketoesters
Author(s) -
Duan HaiFeng,
Xie JianHua,
Qiao XiangChen,
Wang LiXin,
Zhou QiLin
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800423
Subject(s) - rhodium , enantioselective synthesis , catalysis , chemistry , ligand (biochemistry) , solvent , dichloroethane , aqueous medium , organic chemistry , aqueous solution , combinatorial chemistry , receptor , biochemistry
Rhodium catalysis : The first example of a catalytic asymmetric addition of arylboronic acids to α‐ketoesters was realized by using a chiral Rh I –spirophosphite ligand complex in aqueous solvent to provide tertiary α‐hydroxyesters in good yields with high enantioselectivities (see scheme; DCE=1,2‐dichloroethane).
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