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Total Synthesis of Macbecin I
Author(s) -
Belardi Justin K.,
Micalizio Glenn C.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800400
Subject(s) - benzoquinone , total synthesis , biosynthesis , chemistry , aldehyde , alkyne , alkoxide , computer science , combinatorial chemistry , stereochemistry , biochemistry , enzyme , catalysis
Beyond the bounds of biosynthesis : In a step towards the goal of developing a synthetic pathway for the production of collections of complex molecules related to the benzoquinone ansamycin antibiotics, a natural member of this class was synthesized in a convergent manner through the mild titanium alkoxide mediated coupling of the highly functionalized aniline‐containing alkyne 1 with the sensitive polyunsaturated aldehyde 2 .