An Annulation Reaction for the Synthesis of Morpholines, Thiomorpholines, and Piperazines from β‐Heteroatom Amino Compounds and Vinyl Sulfonium Salts | Zendy

Yar Muhammad | Zendy; McGarrigle Eoghan M. | Zendy; Aggarwal Varinder K. | Zendy

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An Annulation Reaction for the Synthesis of Morpholines, Thiomorpholines, and Piperazines from β‐Heteroatom Amino Compounds and Vinyl Sulfonium Salts

Author(s) -

Yar Muhammad,

McGarrigle Eoghan M.,

Aggarwal Varinder K.

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200800373

Subject(s) - sulfonium , synthon , annulation , electrophile , heteroatom , chemistry , dication , salt (chemistry) , base (topology) , organic chemistry , medicinal chemistry , combinatorial chemistry , molecule , ring (chemistry) , catalysis , mathematical analysis , mathematics

Heterocycling: Diphenyl vinyl sulfonium salt 1 acts first as an electrophile, then a base, and then again as an electrophile in this operationally simple, high yielding, one‐pot synthesis of pharmacologically important morpholines, thiomorpholines, and piperazines. Compound 1 is an excellent synthon for the 1,2‐ethane dication.

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