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Catalytic Asymmetric CSi Bond Formation to Acyclic α,β‐Unsaturated Acceptors by Rh I ‐Catalyzed Conjugate Silyl Transfer Using a SiB Linkage
Author(s) -
Walter Christian,
Oestreich Martin
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800361
Subject(s) - enantiopure drug , silylation , silanes , catalysis , chemistry , conjugate , alkyl , aryl , medicinal chemistry , stereochemistry , enantioselective synthesis , organic chemistry , mathematics , mathematical analysis , silane
A perfect match: The Rh I ‐catalyzed conjugate silylation of acyclic Z ‐configured α,β‐unsaturated carboxyl compounds including imides with silylboronic ester yields almost enantiopure α‐chiral quaternary silanes (see scheme; R=aryl and (branched) alkyl, cod=cycloocta‐1,5‐diene, pin=pinacolato).