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Superparamagnetic Nanoparticles as a Powerful Systems Biology Characterization Tool in the Physiological Context
Author(s) -
Salaklang Jatuporn,
Steitz Benedikt,
Finka Andrija,
O'Neil Conlin P.,
Moniatte Marc,
van der Vlies André J.,
Giorgio Todd D.,
Hofmann Heinrich,
Hubbell Jeffrey A.,
PetriFink Alke
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800357
Subject(s) - context (archaeology) , internalization , superparamagnetism , nanoparticle , chemistry , nanotechnology , peptide , characterization (materials science) , isolation (microbiology) , computational biology , biophysics , computer science , biochemistry , biology , materials science , physics , bioinformatics , magnetization , paleontology , quantum mechanics , magnetic field , cell
Spying on SPIONs : Superparamagnetic iron oxide nanoparticles (SPIONs) bearing a mitochondrial targeting peptide (MTP), a cyclic RGD peptide for internalization (cRGD), and a fluorophore for tracking can be targeted to mitochondria. After magnetic isolation from the cells, 48 proteins are identified by mass spectrometry to be interacting with the MTP‐cRGD‐SPIONs in a network that consists of 308 interactions (see picture).