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Copper‐Catalyzed Asymmetric Propargylic Substitution Reactions of Propargylic Acetates with Amines
Author(s) -
Hattori Gaku,
Matsuzawa Hiroshi,
Miyake Yoshihiro,
Nishibayashi Yoshiaki
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800276
Subject(s) - substitution (logic) , enantioselective synthesis , catalysis , chemistry , copper , medicinal chemistry , organic chemistry , combinatorial chemistry , computer science , programming language
Flexing your bipheps : Enantioselective propargylic substitution reactions of propargylic acetates with amines catalyzed by a copper‐( R )‐Cl‐MeO‐biphep or ‐binap complex give the corresponding propargylic amines in excellent yields with up to 89 % ee. The reaction described may provide a novel synthetic method for the preparation of chiral propargylic amines.