Copper‐Catalyzed Asymmetric Propargylic Substitution Reactions of Propargylic Acetates with Amines | Zendy

Hattori Gaku | Zendy; Matsuzawa Hiroshi | Zendy; Miyake Yoshihiro | Zendy; Nishibayashi Yoshiaki | Zendy

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Copper‐Catalyzed Asymmetric Propargylic Substitution Reactions of Propargylic Acetates with Amines

Author(s) -

Hattori Gaku,

Matsuzawa Hiroshi,

Miyake Yoshihiro,

Nishibayashi Yoshiaki

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200800276

Subject(s) - substitution (logic) , enantioselective synthesis , catalysis , chemistry , copper , medicinal chemistry , organic chemistry , combinatorial chemistry , computer science , programming language

Flexing your bipheps : Enantioselective propargylic substitution reactions of propargylic acetates with amines catalyzed by a copper‐( R )‐Cl‐MeO‐biphep or ‐binap complex give the corresponding propargylic amines in excellent yields with up to 89 % ee. The reaction described may provide a novel synthetic method for the preparation of chiral propargylic amines.

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