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Total Synthesis of (−)‐Pestalotiopsin A
Author(s) -
Takao Kenichi,
Hayakawa Nobuhiko,
Yamada Reo,
Yamaguchi Taro,
Morita Urara,
Kawasaki Soujiro,
Tadano Kinichi
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800253
Subject(s) - intramolecular force , total synthesis , aldol reaction , ring (chemistry) , construct (python library) , chemistry , scheme (mathematics) , computer science , content (measure theory) , stereochemistry , cycloaddition , mathematics , organic chemistry , programming language , catalysis , mathematical analysis
A big “+” : The total synthesis of (−)‐pestalotiopsin A has been achieved, thereby establishing the absolute stereochemistry of natural (+)‐pestalotiopsin A (see scheme). The synthesis features a [2+2] cycloaddition, an aldol reaction, and an intramolecular Nozaki–Hiyama–Kishi reaction to construct the ( E )‐cyclononene ring.