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An Electroactive Catalytic Dynamic Substrate that Immobilizes and Releases Patterned Ligands, Proteins, and Cells
Author(s) -
Chan Eugene W. L.,
Park Sungjin,
Yousaf Muhammad N.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800166
Subject(s) - substrate (aquarium) , monolayer , chemistry , catalysis , quinone , combinatorial chemistry , electrochemistry , peptide , nanotechnology , biophysics , stereochemistry , biochemistry , materials science , electrode , biology , ecology
Dynamic release : A quinone‐terminated self‐assembled monolayer captures and releases ligands and cells in situ through a pH‐dependent electrochemical potential. The surface is catalytic for multiple rounds of immobilization/release. When combined with a photochemical approach, peptide ligands that mediate cell attachment are captured and released on defined gradient patterns (see picture).