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Supported Gold(III) Catalysts for Highly Efficient Three‐Component Coupling Reactions
Author(s) -
Zhang Xin,
Corma Avelino
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800098
Subject(s) - component (thermodynamics) , toluene , nanocrystalline material , catalysis , coupling (piping) , sulfonyl , coupling reaction , chemistry , combinatorial chemistry , organic chemistry , computer science , materials science , physics , crystallography , metallurgy , alkyl , thermodynamics
Charged gold species stabilized on nanocrystalline CeO 2 or ZrO 2 are highly active catalysts for the one‐pot, three‐component coupling of aldehydes, amines, and alkynes/N‐protected ethynylaniline, which yields multifunctionalized propargylamines and indoles in good to excellent yields (see picture; Ts=toluene‐4‐sulfonyl).