Sensitive NMR Sensors Detect Antibodies to Influenza | Zendy

Koh Isaac | Zendy; Hong Rui | Zendy; Weissleder Ralph | Zendy; Josephson Lee | Zendy

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Sensitive NMR Sensors Detect Antibodies to Influenza

Author(s) -

Koh Isaac,

Hong Rui,

Weissleder Ralph,

Josephson Lee

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200800069

Subject(s) - homogeneous , particle (ecology) , sensitivity (control systems) , relaxation (psychology) , antibody , influenza a virus , magnetic field , magnetic relaxation , nuclear magnetic resonance , chemistry , materials science , virology , virus , physics , magnetization , immunology , biology , statistical physics , ecology , quantum mechanics , electronic engineering , neuroscience , engineering

Catching the flu : Magnetic particle aggregation has been used to provide a highly sensitive, NMR‐based sensor for detecting antibodies to an influenza virus. To achieve high sensitivity, a homogeneous magnetic field ( H ) was employed to enhance antibody‐based cross‐linking between particles suspended in solution (see scheme; Δ T 2 : change in the transverse relaxation time).

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