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Sensitive NMR Sensors Detect Antibodies to Influenza
Author(s) -
Koh Isaac,
Hong Rui,
Weissleder Ralph,
Josephson Lee
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800069
Subject(s) - homogeneous , particle (ecology) , sensitivity (control systems) , relaxation (psychology) , antibody , influenza a virus , magnetic field , magnetic relaxation , nuclear magnetic resonance , chemistry , materials science , virology , virus , physics , magnetization , immunology , biology , statistical physics , ecology , quantum mechanics , electronic engineering , neuroscience , engineering
Catching the flu : Magnetic particle aggregation has been used to provide a highly sensitive, NMR‐based sensor for detecting antibodies to an influenza virus. To achieve high sensitivity, a homogeneous magnetic field ( H ) was employed to enhance antibody‐based cross‐linking between particles suspended in solution (see scheme; Δ T 2 : change in the transverse relaxation time).