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Total Synthesis of Platencin
Author(s) -
Nicolaou K. C.,
Tria G. Scott,
Edmonds David J.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200800066
Subject(s) - antibiotics , staphylococcus aureus , streptomyces , bacteria , linezolid , microbiology and biotechnology , vancomycin , chemistry , antibiotic resistance , methicillin resistant staphylococcus aureus , biology , stereochemistry , genetics
The asymmetric total synthesis of the newly discovered and potent antibiotic platencin has been achieved. The approach makes use of an asymmetric Diels–Alder reaction, a gold(I)‐catalyzed cyclization, and a homoallyl radical rearrangement to forge the polycyclic architecture of this intriguing target (see scheme, SEM=2‐(trimethylsilyl)ethoxymethyl).
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