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Cover Picture: Ruthenium‐Catalyzed Enantioselective Propargylation of Aromatic Compounds with Propargylic Alcohols via Allenylidene Intermediates (Angew. Chem. Int. Ed. 34/2007)
Author(s) -
Matsuzawa Hiroshi,
Miyake Yoshihiro,
Nishibayashi Yoshiaki
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200790166
Subject(s) - enantioselective synthesis , ruthenium , catalysis , friedel–crafts reaction , chemistry , electrophile , organic chemistry , alkylation , combinatorial chemistry
Ruthenium‐catalyzed enantioselective propargylation of aromatic compounds, such as furans and N , N ‐dimethylaniline, with propargylic alcohols afforded the corresponding propargylated aromatic compounds, as the first example of asymmetric propargylation of aromatic compounds. In their Communication on page 6488 ff., Y. Nishibayashi et al. develop the method to provide a novel asymmetric Friedel–Crafts alkylation of aromatic compounds by using propargylic alcohols as a new type of electrophile.