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Cover Picture: Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2 (Angew. Chem. Int. Ed. 27/2007)
Author(s) -
Gey Claudia,
Kyrylenko Sergiy,
Hennig Lothar,
Nguyen LienHoa D.,
Büttner Anita,
Pham Hung D.,
Giannis Athanassios
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200790122
Subject(s) - hyperforin , phloroglucinol , hypericum perforatum , sirt2 , chemistry , pharmacology , hypericum , stereochemistry , traditional medicine , medicine , sirtuin , biochemistry , enzyme , nad+ kinase , organic chemistry
Hippocrates (the father of medicine) described the healing properties of St. John's wort 2500 years ago and prescribed it for the treatment of depression. Hyperforin, which is considered to be responsible for this activity, also has anticancer, antibacterial, and wound‐healing activity. A. Giannis et al. describe in their Communication on page 5219 ff. that hyperforin and two related compounds are inhibitors of sirtuins SIRT1 and SIRT2. This property could explain some of the pharmacological properties of hyperforin.