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Cover Picture: A Glycosynthase Catalyst for the Synthesis of Flavonoid Glycosides (Angew. Chem. Int. Ed. 21/2007)
Author(s) -
Yang Min,
Davies Gideon J.,
Davis Benjamin G.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200790091
Subject(s) - chemistry , cover (algebra) , glycoside , glycosyltransferase , mutant , stereochemistry , combinatorial chemistry , computational biology , enzyme , biochemistry , biology , engineering , gene , mechanical engineering
A panoramic library: Multiwell library screening of acceptor structures has allowed the identification of the first examples of glycosynthase enzymes that utilize non‐natural substrates. In their Communication on page 3885 ff., G. Davies, B. Davis, and M. Yang show that the novel specificity, activity, and catalytic efficiency of the mutants are comparable with those of natural glycosyltransferases. The cover shows a 360° view of the “multiwell” ceiling of Oxford's Radcliffe Science Library.