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Inside Cover: Direct Monitoring of Formation and Dissociation of Individual Metal Complexes by Single‐Molecule Fluorescence Spectroscopy (Angew. Chem. Int. Ed. 18/2007)
Author(s) -
Kiel Alexander,
Kovacs Janos,
Mokhir Andriy,
Krämer Roland,
Herten DirkPeter
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200790076
Subject(s) - dissociation (chemistry) , fluorescence , molecule , fluorescence spectroscopy , spectroscopy , chemistry , kinetics , metal , nanotechnology , chemical physics , materials science , organic chemistry , physics , quantum mechanics
Single‐molecule spectroscopy has proven a versatile tool in biochemistry and molecular biology. In their Communication on page 3363 ff., D. P. Herten et al. describe the first application of this technique to chemical reactions of small molecules by observing the association and dissociation of a Cu 2+ complex in real time. By the use of confocal microscopy and by designing a fluorescent metal sensor that can be immobilized on glass slides, they were able to obtain the kinetics of individual complexes in thermodynamic equilibrium.