Premium
Inside Cover: O‐Glycoside Orientation Is an Essential Aspect of Base J Recognition by the Kinetoplastid DNA‐Binding Protein JBP1 (Angew. Chem. Int. Ed. 16/2007)
Author(s) -
Grover Rajesh K.,
Pond Stephanie J. K.,
Cui Qizhi,
Subramaniam Prem,
Case David A.,
Millar David P.,
Wentworth Paul
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200790063
Subject(s) - dna , nucleoside , ring (chemistry) , stereochemistry , chemistry , biology , microbiology and biotechnology , biochemistry , computational biology , organic chemistry
Protein recognition of DNA is key to the control of genome expression within living cells. Kinetoplastid parasites like those in the background possess the protein JBP1, which binds to double‐stranded DNA containing the glycosylated base shown (nucleoside dJ). In their Communication on page 2839 ff., P. Wentworth, Jr. et al. analyze the binding and find that JBP1 recognizes a critical edge‐on conformation of the pyranosyl ring of nucleoside dJ. These results are important for the development of new biological targets for antiparasitic drugs.