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Inside Cover: Multiplication of Human Natural Killer Cells by Nanosized Phosphonate‐Capped Dendrimers (Angew. Chem. Int. Ed. 14/2007)
Author(s) -
Griffe Laurent,
Poupot Mary,
Marchand Patrice,
Maraval Alexandrine,
Turrin CédricOlivier,
Rolland Olivier,
Métivier Pascal,
Bacquet Gérard,
Fournié JeanJacques,
Caminade AnneMarie,
Poupot Rémy,
Majoral JeanPierre
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200790051
Subject(s) - dendrimer , phosphonate , peripheral blood mononuclear cell , chemistry , peripheral blood , fluorescence , biology , immunology , biochemistry , in vitro , physics , quantum mechanics
Human peripheral blood mononuclear cells (white blood cells) cultured in the presence of dendrimers capped with phosphonate groups reveal a selective multiplication of natural killer (NK) cells. In their Communication on page 2523 ff., A.‐M. Caminade, R. Poupot, J.‐P. Majoral, and co‐workers describe the synthesis of various phosphazene dendrimers and their effect on NK cells, which play a key role in anticancer immunity. The picture shows a fluorescence microscopy image of a NK cell (red) engaged with target cancer cells (green).