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Inside Cover: Rapid In Vivo Fingerprinting of Nonvolatile Compounds in Breath by Extractive Electrospray Ionization Quadrupole Time‐of‐Flight Mass Spectrometry (Angew. Chem. Int. Ed. 4/2007)
Author(s) -
Chen Huanwen,
Wortmann Arno,
Zhang Weihua,
Zenobi Renato
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200790001
Subject(s) - mass spectrometry , extractive electrospray ionization , electrospray ionization , chemistry , analytical chemistry (journal) , electrospray , ion source , ionization , chromatography , ambient ionization , breath gas analysis , quadrupole time of flight , time of flight mass spectrometry , triple quadrupole mass spectrometer , time of flight , ion , tandem mass spectrometry , sample preparation in mass spectrometry , chemical ionization , selected reaction monitoring , organic chemistry
Metabolic dynamics can be followed in real time by mass spectral fingerprints of breath by extractive electrospray ionization (EESI) quadrupole TOF mass spectrometry on a commercial instrument. Neither sample pretreatment nor hardware modifications are necessary for this rapid, online, and in vivo method. Furthermore, selective ion/molecule reactions in the EESI interface can lead to the detection of interesting compounds. For more details see the Communication by R. Zenobi and co‐workers on page 580ff.