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Betablockers at Work: The Crystal Structure of the β 2 ‐Adrenergic Receptor
Author(s) -
Hausch Felix
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705971
Subject(s) - g protein coupled receptor , receptor , adrenergic receptor , ligand (biochemistry) , β2 adrenergic receptor , rational design , action (physics) , chemistry , computational biology , physics , stereochemistry , biology , biochemistry , genetics , agonist , quantum mechanics
Rational drug design is still limited for many membrane proteins. For the β 2 ‐adrenergic receptor, a prototype of the class A GPCR family, structures with up to 2.4‐Å resolution have now been solved. The structure (see figure) shows detailed contacts of the receptor (green) with its ligand carazolol (pink), and makes possible the formulation of hypotheses for the mode of action of G‐protein‐coupled receptors.