Cholesterol  seco ‐Sterol‐Induced Aggregation of Methylated Amyloid‐β Peptides—Insights into Aldehyde‐Initiated Fibrillization of Amyloid‐β | Zendy

Scheinost Johanna C. | Zendy; Wang Hong | Zendy; Boldt Grant E. | Zendy; Offer John | Zendy; Wentworth Paul | Zendy

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Cholesterol seco ‐Sterol‐Induced Aggregation of Methylated Amyloid‐β Peptides—Insights into Aldehyde‐Initiated Fibrillization of Amyloid‐β

Author(s) -

Scheinost Johanna C.,

Wang Hong,

Boldt Grant E.,

Offer John,

Wentworth Paul

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200705922

Subject(s) - chemistry , amyloid (mycology) , biochemistry , peptide , sterol , cholesterol , small molecule , inorganic chemistry

Hot spot on amyloid‐β? Atheronal‐B‐induced aggregation of amyloid‐β (Aβ) involves a site‐specific adduction of the aldehyde to the ε‐amino group of Lys 16, suggesting that Lys 16 is a hot spot for atheronal‐induced fibrillization of Aβ (see scheme). This process can be inhibited by molecules like cholesterol that compete for the central hydrophobic cluster binding domain.

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