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Cholesterol seco ‐Sterol‐Induced Aggregation of Methylated Amyloid‐β Peptides—Insights into Aldehyde‐Initiated Fibrillization of Amyloid‐β
Author(s) -
Scheinost Johanna C.,
Wang Hong,
Boldt Grant E.,
Offer John,
Wentworth Paul
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705922
Subject(s) - chemistry , amyloid (mycology) , biochemistry , peptide , sterol , cholesterol , small molecule , inorganic chemistry
Hot spot on amyloid‐β? Atheronal‐B‐induced aggregation of amyloid‐β (Aβ) involves a site‐specific adduction of the aldehyde to the ε‐amino group of Lys 16, suggesting that Lys 16 is a hot spot for atheronal‐induced fibrillization of Aβ (see scheme). This process can be inhibited by molecules like cholesterol that compete for the central hydrophobic cluster binding domain.