Premium
Silicon‐Based Building Blocks for One‐Step 18 F‐Radiolabeling of Peptides for PET Imaging
Author(s) -
Mu Linjing,
Höhne Aileen,
Schubiger P. August,
Ametamey Simon M.,
Graham Keith,
Cyr John E.,
Dinkelborg Ludger,
Stellfeld Timo,
Srinivasan Ananth,
Voigtmann Ulrike,
Klar Ulrich
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705854
Subject(s) - positron emission tomography , linker , tetrapeptide , hydrolysis , chemistry , computer science , pet imaging , derivative (finance) , in vivo , combinatorial chemistry , nanotechnology , nuclear medicine , materials science , peptide , programming language , organic chemistry , biochemistry , medicine , microbiology and biotechnology , biology , financial economics , economics
Radio‐controlled landing of F : The facile 18 F labeling of biomolecules has been achieved under mild conditions by using a unique silicon‐based one‐step approach (see scheme). A di‐ tert ‐butylsilyl derivative with an aryl linker was attached to a tetrapeptide. The assembly shows a hydrolytic stability that appears to be within the range required for in vivo positron emission tomography (PET) imaging applications.