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Selective Oxidation of Aliphatic CH Bonds in the Synthesis of Complex Molecules
Author(s) -
Christmann Mathias
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705766
Subject(s) - catalysis , yield (engineering) , chemistry , environmentally friendly , natural product , combinatorial chemistry , oxidation process , molecule , metal , organic chemistry , chemical engineering , materials science , ecology , engineering , metallurgy , biology
Tamed cat : Iron‐catalyzed selective CH oxidation reactions present new possibilities in the synthesis and modification of natural products. As a model reaction of a possible CH oxidation as part of a total synthesis, the natural product (+)‐artemisinin was converted into (+)‐10β‐hydroxyartemisinin in 34 % yield (see scheme). The combination of nontoxic metal catalyst with H 2 O 2 is an environmentally friendly process.