Enantioselective Phase‐Transfer‐Catalyzed Intramolecular Aza‐Michael Reaction: Effective Route to Pyrazino‐Indole Compounds | Zendy

Bandini Marco | Zendy; Eichholzer Astrid | Zendy; Tragni Michele | Zendy; UmaniRonchi Achille | Zendy

Premium

Enantioselective Phase‐Transfer‐Catalyzed Intramolecular Aza‐Michael Reaction: Effective Route to Pyrazino‐Indole Compounds

Author(s) -

Bandini Marco,

Eichholzer Astrid,

Tragni Michele,

UmaniRonchi Achille

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200705685

Subject(s) - intramolecular force , indole test , enantioselective synthesis , catalysis , chemistry , ring (chemistry) , combinatorial chemistry , phase (matter) , stereochemistry , organic chemistry

Producing polycycles : A mild and direct stereocontrolled route to pharmacologically active pyrazino‐indol‐1‐ones has been developed. The optimal phase‐transfer conditions provide variously functionalized ring‐closed compounds in high chemical and optical yields (see scheme; X=H, F, Cl, Me, OMe; Ar=Ph, β‐naphthyl; R′= t Bu, Et, Me; R=benzyl, para ‐methoxyphenyl).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research