Enantioselective O‐Nitroso Aldol Reaction of Silyl Enol Ethers | Zendy

Kawasaki Masanori | Zendy; Li Pingfan | Zendy; Yamamoto Hisashi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Enantioselective O‐Nitroso Aldol Reaction of Silyl Enol Ethers

Author(s) -

Kawasaki Masanori,

Li Pingfan,

Yamamoto Hisashi

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200705679

Subject(s) - aldol reaction , enol , silylation , chemistry , trimethylsilyl , nucleophile , regioselectivity , enantioselective synthesis , nitroso , catalysis , ligand (biochemistry) , organic chemistry , combinatorial chemistry , biochemistry , receptor

New nucleophiles for the O‐nitroso aldol reaction in the form of readily prepared disilanyl enol ethers make this transformation more practical and more versatile. A silver catalyst with a chiral biaryl phosphite ligand promotes the title reaction with high enantio‐ and regioselectivity (see scheme). R 1 ,R 2 = H, Ar; TMS = trimethylsilyl.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research