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Iron‐Catalyzed S‐Arylation of Thiols with Aryl Iodides
Author(s) -
Correa Arkaitz,
Carril Mónica,
Bolm Carsten
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705668
Subject(s) - aryl , catalysis , chemistry , combinatorial chemistry , organic chemistry , alkyl
Strike while the iron is hot : An efficient iron‐catalyzed protocol for the S‐arylation of aromatic and heteroaromatic thiol derivatives has been developed, which involves an inexpensive catalyst system formed by combining FeCl 3 and N , N ′‐dimethylethylenediamine at 135 °C. This method avoids the use of expensive and/or air‐sensitive ligands and provides in most cases the desired sulfide in high yields.