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Mesoporous Silica Nanosphere Supported Ruthenium Catalysts for Asymmetric Hydrogenation
Author(s) -
Mihalcik David J.,
Lin Wenbin
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705656
Subject(s) - ruthenium , catalysis , chemistry , mesoporous silica , aryl , mesoporous material , asymmetric hydrogenation , enantioselective synthesis , organic chemistry , combinatorial chemistry , noyori asymmetric hydrogenation , diamine , alkyl
Chiral Ruthenium–diphosphine–diamine complexes with a siloxy pendant are grafted onto mesoporous silica nanospheres. The resulting supported ruthenium catalysts are highly active for the asymmetric hydrogenation of aromatic ketones to afford chiral secondary alcohols and racemic aryl aldehydes to give chiral primary alcohols (see scheme). This immobilization strategy should be amenable to the design of similar heterogeneous catalysts.