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A Heterobimetallic Pd/La/Schiff Base Complex for anti ‐Selective Catalytic Asymmetric Nitroaldol Reactions and Applications to Short Syntheses of β‐Adrenoceptor Agonists
Author(s) -
Handa Shinya,
Nagawa Keita,
Sohtome Yoshihiro,
Matsunaga Shigeki,
Shibasaki Masakatsu
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705617
Subject(s) - schiff base , catalysis , chemistry , selectivity , combinatorial chemistry , stereochemistry , organic chemistry
Two metals in a pod : The combination of Pd and La with a dinucleating Schiff base was developed for anti selectivity in the catalytic asymmetric nitroaldol reaction (see scheme). Short syntheses of β‐adrenoceptor agonists by using the heterobimetallic catalyst are presented.