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Exploring the Differential Recognition of DNA G‐Quadruplex Targets by Small Molecules Using Dynamic Combinatorial Chemistry
Author(s) -
Bugaut Anthony,
Jantos Katja,
Wietor JeanLuc,
Rodriguez Raphaël,
Sanders Jeremy K. M.,
Balasubramanian Shankar
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200705589
Subject(s) - nucleic acid , chemistry , g quadruplex , dna , cationic polymerization , binding affinities , combinatorial chemistry , small molecule , oxazole , computational biology , carbohydrate chemistry , affinities , peptide nucleic acid , biochemistry , biology , organic chemistry , receptor
Tuning affinities : Dynamic combinatorial chemistry has been employed to explore the effect of chemical modifications on the DNA G‐quadruplex binding properties of an oxazole‐based peptide macrocycle. Two dynamic libraries of molecules, containing cationic and carbohydrate motifs, respectively, were screened by using structurally diverse nucleic acid targets (see scheme; each colored shape represents a cation or carbohydrate).